One guru said, "More than 5 reps is cardio!"
Yes, there is a little more to 5 reps than the original statement by one of the early proponents of the "5x5" set and rep- scheme.
Bill Starr said, "It sounded good."
It works well, too, but only up to a point and with a lot of time and effort.
Strength newbies "hit the wall" after a few months and often start "program hopping" because nothing really fits as well as advertised.
Jim Wendler's 5/3/1 could be the next serious program that can work for folks with a lot of time and a big fridge.
One of world-record-holder Matt Wenning's programs could also deliver results if you like his extended warm-ups and maximum efforts.
Oh, and RTS by Mike Tuchscherer is obviously a good one...
But, wait a minute, ...
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Matt Wenning had great success with HUNDREDS of reps per training-session!
Multiple Sets of 25 reps!
I could ask:
"He did more than 5 reps!
A world record with cardio?!"
Meathead's answer:
"No, No, it's the max effort! (...)"
But Matt insists that his high-rep program was the key factor that made him (and thousands of TACTICAL personal he trained) STRONG AF!
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Dr. Michael Yessis has written about 1x20 reps and a lot of different exercises...
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"Super Squats" by Randall Strossen is one of the best programs ever! 1 set! 20 reps!
4, 5, 25 or 20... THESE ARE JUST NUMBERS!
EVERYTHING WORKS if you CONSTANTLY CHANGE THE STIMULUS, OVERLOAD PROGRESSIVELY and FIND YOUR WAY between "too easy" and "too hard"!
5x5 reps are not always the best choice, especially when you are able to lift the same weight for 3x10 reps. It's clearly not the smartest choice for folks with limited time.
Key questions:
What are my GOALS?
Are my planned actions leading me to my goals?
Are there conflicting actions?
Will my plan be SUSTAINABLE FOR ME?
The last question cannot be answered without TRIAL AND ERROR!
Start as easy as reasonable:
1 set (fewer sets are impossible)
A very light weight.
Enough repetitions to stimulate a response from your body.
In the next training session, increase the weight and adjust the sets and repetitions.
Take notes and observe how your body responds.
Figure out which stimulus works best for your goals.
That's all you really need to do!
My method to change the stimulus is explained Here.